Influence of the Number of Axial Bexarotene Ligands on the Cytotoxicity of Pt(IV) Analogs of Oxaliplatin

Yulia N. Nosova; Ilia V. Zenin; Varvara P. Maximova; Ekaterina M. Zhidkova; Kirill I. Kirsanov; Ekaterina A. Lesovaya; Anna A. Lobas; Mikhail V. Gorshkov; Olga N. Kovaleva; Elena R. Milaeva; Markus Galanski; Bernhard K. Keppler; Alexey A. Nazarov

doi:10.1155/2017/4736321

Bioinorganic Chemistry and Applications (Jan 2017)

Influence of the Number of Axial Bexarotene Ligands on the Cytotoxicity of Pt(IV) Analogs of Oxaliplatin

Yulia N. Nosova,
Ilia V. Zenin,
Varvara P. Maximova,
Ekaterina M. Zhidkova,
Kirill I. Kirsanov,
Ekaterina A. Lesovaya,
Anna A. Lobas,
Mikhail V. Gorshkov,
Olga N. Kovaleva,
Elena R. Milaeva,
Markus Galanski,
Bernhard K. Keppler,
Alexey A. Nazarov

Affiliations

Yulia N. Nosova: Department of Medicinal Chemistry and Fine Organic Synthesis, Lomonosov Moscow State University, Leninskie Gory 1/3, Moscow 119991, Russia
Ilia V. Zenin: Department of Medicinal Chemistry and Fine Organic Synthesis, Lomonosov Moscow State University, Leninskie Gory 1/3, Moscow 119991, Russia
Varvara P. Maximova: Blokhin Cancer Research Center, 24 Kashirskoye Shosse, Moscow 115478, Russia
Ekaterina M. Zhidkova: Blokhin Cancer Research Center, 24 Kashirskoye Shosse, Moscow 115478, Russia
Kirill I. Kirsanov: Blokhin Cancer Research Center, 24 Kashirskoye Shosse, Moscow 115478, Russia
Ekaterina A. Lesovaya: Blokhin Cancer Research Center, 24 Kashirskoye Shosse, Moscow 115478, Russia
Anna A. Lobas: Institute for Energy Problems of Chemical Physics, Russian Academy of Sciences, Leninsky Pr. 38, Bld.2, Moscow 119334, Russia
Mikhail V. Gorshkov: Institute for Energy Problems of Chemical Physics, Russian Academy of Sciences, Leninsky Pr. 38, Bld.2, Moscow 119334, Russia
Olga N. Kovaleva: I.M. Sechenov First Moscow State Medical University, Moscow, Russia
Elena R. Milaeva: Department of Medicinal Chemistry and Fine Organic Synthesis, Lomonosov Moscow State University, Leninskie Gory 1/3, Moscow 119991, Russia
Markus Galanski: Faculty of Chemistry, Institute of Inorganic Chemistry, University of Vienna, Waehringer Str. 42, 1019 Vienna, Austria
Bernhard K. Keppler: Faculty of Chemistry, Institute of Inorganic Chemistry, University of Vienna, Waehringer Str. 42, 1019 Vienna, Austria
Alexey A. Nazarov: Department of Medicinal Chemistry and Fine Organic Synthesis, Lomonosov Moscow State University, Leninskie Gory 1/3, Moscow 119991, Russia

DOI: https://doi.org/10.1155/2017/4736321
Journal volume & issue: Vol. 2017

Abstract

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We present the synthesis and cytotoxic potencies of new Pt(IV) complexes with bexarotene, an anticancer drug that induces cell differentiation and apoptosis via selective activation of retinoid X receptors. In these complexes bexarotene is positioned as an axial ligand. The complex of one bexarotene ligand attached to Pt(IV) oxaliplatin moiety was potent whereas its counterpart carrying two bexarotene ligands was inactive.

Published in Bioinorganic Chemistry and Applications

ISSN: 1565-3633 (Print); 1687-479X (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Technology: Chemical technology: Biotechnology; Science: Chemistry: Inorganic chemistry
Website: https://onlinelibrary.wiley.com/journal/4036

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