Non-High-Density lipoprotein cholesterol or Apolipoprotein B in the prediction of myocardial infarction

Abstract

Background: It is well documented that elevated Low Density Lipoprotein cholesterol (LDL-C) is one of cardiovascular risk. However, not all patients of coronary heart disease possess elevated LDL-C level. There is a growing evidences that non-high density lipoprotein (non-HDL) cholesterol and Apo B carry on all of the potentially proatherogenic lipoproteins apart from LDL-C. The study was conducted to search the role of non-HDL(C) and ApoB as alternative to LDL-C for the better and useful predictor of myocardial infarction (MI). Methods: In this cross-sectional study, hundred patients of MI and 100 controls of age and sex matched were studied for LDL-C, non-HDL(C) and Apo B between March 2014 and April 2015 in the Department Cardiology and Biochemistry. Result: The data was analyzed using SPSS 11.5. Serum concentration of both non-HDL cholesterol and ApoB in cases is significantly higher than controls but no significant differences in concentration of serum LDL-C (Student’s t test). On regression analysis it was shown that serum non-HDLC is better correlated with apo B than is LDL-C. On ROC curve analysis, it was found that non-HDL(C) had both the sensitivity and the negative predictive value 100% and 95.1%, whereas specificity and positive predictive value of Apo B were 96% and 94.6% respectively. On the other hand sensitivity and negative predictive value were 100% and 96.3%, whereas specificity and positive predictive value were 95% and 95.7% respectively. Conclusion: Both apoB and non–HDL-C was better predictor of MI than LDL-C and among these two, non-HDL(C) is much better.

Keywords

• ApoB
• Low Density Lipoprotein cholesterol
• Myocardial infarction
• Non-High Density Lipoprotein