Vastly extended drug release from poly(pro-17β-estradiol) materials facilitates in vitro neurotrophism and neuroprotection

Anthony R. D’Amato; Devan L. Puhl; Samuel A. T. Ellman; Bailey Balouch; Ryan J. Gilbert; Edmund F. Palermo

doi:10.1038/s41467-019-12835-w

Nature Communications (Oct 2019)

Vastly extended drug release from poly(pro-17β-estradiol) materials facilitates in vitro neurotrophism and neuroprotection

Anthony R. D’Amato,
Devan L. Puhl,
Samuel A. T. Ellman,
Bailey Balouch,
Ryan J. Gilbert,
Edmund F. Palermo

Affiliations

Anthony R. D’Amato: Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute
Devan L. Puhl: Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute
Samuel A. T. Ellman: Materials Science and Engineering, Rensselaer Polytechnic Institute
Bailey Balouch: Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute
Ryan J. Gilbert: Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute
Edmund F. Palermo: Materials Science and Engineering, Rensselaer Polytechnic Institute

DOI: https://doi.org/10.1038/s41467-019-12835-w
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 12

Abstract

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Currently there are no therapeutics for long lasting central nervous system injuries, that can address the complex injury cascade that develops over years. Here the authors report biomaterial scaffolds that release 17β-estradiol (E2) at nanomolar concentrations over the course of 1–10 years via slow hydrolysis in vitro.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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