Prognostic value of microcirculatory changes and alterations in the cellular microenvironment in patients with glandular hyperplasia of the endometrium and endometrial cancer (literature review)

Abstract

This article summarizes the results of the most recent studies exploring changes in the stromal component of the endometrial tissue during malignant transformation in patients with precancerous conditions, particularly transformation of glandular hyperplasia of the endometrium into endometrioid adenocarcinoma. We cover the most important issues related to microcirculatory remodeling and changes in the cellular microenvironment of the stroma in terms of the effects exerted by biologically active molecules produced by different cell populations. We analyzed specific changes occurring in the stromal components in various types of glandular hyperplasia of the endometrium and changes during endometrioid adenocarcinoma progression. We focus on the prognostic and diagnostic values of these morphological changes, considering the results of the latest molecular studies, which can be later used for personalization of patient prognosis.

Keywords

• glandular hyperplasia of the endometrium
• endometrioid adenocarcinoma
• microcirculatory bed
• macrophages
• fibroblasts
• lymphocytes