Clinical Interventions in Aging (Apr 2022)
The Association of Plasma Amyloid-β and Cognitive Decline in Cognitively Unimpaired Population
Abstract
Jin Wang,1,* Ling Gao,1,* Jie Liu,1 Liangjun Dang,1 Shan Wei,1 Ningwei Hu,1 Yao Gao,1 Wei Peng,1 Suhang Shang,1 Kang Huo,1 Jingyi Wang,2 Qiumin Qu1,3 1Department of Neurology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China; 2Huyi Hospital of Traditional Chinese Medicine, Xi’an, People’s Republic of China; 3Center for Brain Science, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qiumin Qu, Department of Neurology, The First Affiliated Hospital of Xi’an Jiaotong University, 277 West Yanta Road, Xi’an, 710061, People’s Republic of China, Tel/Fax +86 29 8532 4083, Email [email protected]: This study investigates the relationship between baseline plasma Aβ and cognitive decline during follow-up in cognitively unimpaired population.Materials and Methods: Cognitively unimpaired population was selected from people who lived in the suburbs of Xi’an, China. The levels of plasma Aβ1-42 and Aβ1-40 were tested using commercial enzyme-linked immunosorbent assay (ELISA). The mini-mental state examination (MMSE) and neuropsychological battery were used to assess cognition. Two years later, MMSE was tested again, and significant cognitive decline was defined as a decrease in MMSE scores ≥ 5 points. Logistic regression analysis was performed to analyze the relationship between baseline plasma Aβ and cognitive change during the two-year follow-up.Results: A total of 1144 participants completed the study, among whom 59 subjects (5.2%) presented significant cognitive decline. The high plasma Aβ1-42 level group had more significant cognitive decline (P = 0.023). Multivariable logistic regression analysis showed that significant cognitive decline was associated with the high levels of baseline plasma Aβ1-42 (OR = 1.043, 95% CI: 1.005– 1.083, P = 0.026). However, significant cognitive decline was not associated with baseline plasma Aβ1-40 levels and Aβ1-42 /Aβ1-40 ratio.Conclusion: Population with high level of baseline plasma Aβ1-42 manifested significant cognitive decline over 2 years; however, further investigation on the dynamics of plasma Aβ and long-term follow-up are needed.Keywords: Alzheimer’s disease, cognitive decline, plasma amyloid β, cohort study, plasma biomarker
