Synthesis, Crystal Structures, Antimicrobial Activity, and Acute Toxicity Evaluation of Chiral Zn(II) Schiff Base Complexes
Daniela Gutiérrez Arguelles,
Claudia P. Villamizar,
Eduardo Brambila-Colombres,
Bertin Anzaldo,
Angel Mendoza,
Guadalupe Hernández Téllez,
Pankaj Sharma
Affiliations
Daniela Gutiérrez Arguelles
Laboratory Síntesis de Complejos, Faculty Ciencias Químicas, Universidad Autónoma de Puebla, Edif. FCQ-6, C.U. Av. San Claudio y Blvd. 14 Sur, Col. San Manuel, Puebla C.P. 72592, Mexico
Claudia P. Villamizar
Instituto de Química-UNAM, Circuito Exterior, C.U. Coyoacán, Mexico City C.P. 04510, Mexico
Eduardo Brambila-Colombres
Laboratory Síntesis de Complejos, Faculty Ciencias Químicas, Universidad Autónoma de Puebla, Edif. FCQ-6, C.U. Av. San Claudio y Blvd. 14 Sur, Col. San Manuel, Puebla C.P. 72592, Mexico
Bertin Anzaldo
Laboratory Síntesis de Complejos, Faculty Ciencias Químicas, Universidad Autónoma de Puebla, Edif. FCQ-6, C.U. Av. San Claudio y Blvd. 14 Sur, Col. San Manuel, Puebla C.P. 72592, Mexico
Angel Mendoza
Centro de Química del Instituto de Ciencias, Benemérita Universidad Autónoma de Puebla, 18 Sur y Av. San Claudio, Col. San Manuel, Puebla C.P. 72570, Mexico
Guadalupe Hernández Téllez
Laboratory Síntesis de Complejos, Faculty Ciencias Químicas, Universidad Autónoma de Puebla, Edif. FCQ-6, C.U. Av. San Claudio y Blvd. 14 Sur, Col. San Manuel, Puebla C.P. 72592, Mexico
Pankaj Sharma
Instituto de Química-UNAM, Circuito Exterior, C.U. Coyoacán, Mexico City C.P. 04510, Mexico
Four mononuclear bioefficient zinc coordination complexes [Zn(NN)3](ClO4)2 (A–D) involving chiral bidentate Schiff base ligands have been synthesized and characterized by IR, 1H, and 13C NMR spectroscopy and mass spectrometry. X-ray crystal structures of three of the zinc complexes revealed that the zinc metal ion is hexacoordinated, exhibiting a distorted octahedral geometry where both the nitrogen atoms (NN = pyridyl and imine) of imines are coordinated to the central zinc ion. The isolated zinc complexes were evaluated for their antimicrobial activity in vitro against Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus, displaying varying levels of growth inhibition. An acute toxicity test conducted using Artemia salina and Swiss albino mice showed that the zinc complexes A–D were non-toxic towards A. salina at concentrations below 414, 564, 350, and 385 µM, respectively, and did not affect liver biochemical parameters, although pyknosis was induced in hepatocytes of the treated mice.
