One Step Regioselective Synthesis of 5-Aminoisoxazoles from Nitrile Oxides and α-Cyanoenamines

Abstract

The 1,3-dipolar cycloaddition of nitrile oxides to 1-cyanoenamines gives 5-aminoisoxazoles regioselectively. Moderate to good yields could be obtained depending on the method used to generate the nitrile oxides. The intermediate isoxazolines could not be isolated.

Keywords

• 1-Cyanoenamines
• nitrile oxides
• 1
• 3-dipolar cycloaddition
• 5-amino- isoxazoles.