Nature Communications (May 2019)
Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR-Cas9 screening
- Gabriele Picco,
- Elisabeth D. Chen,
- Luz Garcia Alonso,
- Fiona M. Behan,
- Emanuel Gonçalves,
- Graham Bignell,
- Angela Matchan,
- Beiyuan Fu,
- Ruby Banerjee,
- Elizabeth Anderson,
- Adam Butler,
- Cyril H. Benes,
- Ultan McDermott,
- David Dow,
- Francesco Iorio,
- Euan Stronach,
- Fengtang Yang,
- Kosuke Yusa,
- Julio Saez-Rodriguez,
- Mathew J. Garnett
Affiliations
- Gabriele Picco
- Wellcome Sanger Institute
- Elisabeth D. Chen
- Wellcome Sanger Institute
- Luz Garcia Alonso
- European Molecular Biology Laboratory, European Bioinformatics Institute
- Fiona M. Behan
- Wellcome Sanger Institute
- Emanuel Gonçalves
- Wellcome Sanger Institute
- Graham Bignell
- Wellcome Sanger Institute
- Angela Matchan
- Wellcome Sanger Institute
- Beiyuan Fu
- Wellcome Sanger Institute
- Ruby Banerjee
- Wellcome Sanger Institute
- Elizabeth Anderson
- Wellcome Sanger Institute
- Adam Butler
- Wellcome Sanger Institute
- Cyril H. Benes
- Massachusetts General Hospital
- Ultan McDermott
- Wellcome Sanger Institute
- David Dow
- Open Targets
- Francesco Iorio
- Wellcome Sanger Institute
- Euan Stronach
- Open Targets
- Fengtang Yang
- Wellcome Sanger Institute
- Kosuke Yusa
- Wellcome Sanger Institute
- Julio Saez-Rodriguez
- European Molecular Biology Laboratory, European Bioinformatics Institute
- Mathew J. Garnett
- Wellcome Sanger Institute
- DOI
- https://doi.org/10.1038/s41467-019-09940-1
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 12
Abstract
Gene fusions are observed in many cancers but their link to tumour fitness is largely unknown. Here, transcriptomic analysis combined with pharmacological and CRISPR-Cas9 screening of cancer cell lines was used to evaluate the functional linkage between fusions and tumour fitness.
