Nature Communications (Feb 2020)
De novo emergence of adaptive membrane proteins from thymine-rich genomic sequences
- Nikolaos Vakirlis,
- Omer Acar,
- Brian Hsu,
- Nelson Castilho Coelho,
- S. Branden Van Oss,
- Aaron Wacholder,
- Kate Medetgul-Ernar,
- Ray W. Bowman,
- Cameron P. Hines,
- John Iannotta,
- Saurin Bipin Parikh,
- Aoife McLysaght,
- Carlos J. Camacho,
- Allyson F. O’Donnell,
- Trey Ideker,
- Anne-Ruxandra Carvunis
Affiliations
- Nikolaos Vakirlis
- Smurfit Institute of Genetics, Trinity College Dublin, University of Dublin
- Omer Acar
- Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh
- Brian Hsu
- Department of Medicine, Division of Medical Genetics, University of California San Diego
- Nelson Castilho Coelho
- Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh
- S. Branden Van Oss
- Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh
- Aaron Wacholder
- Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh
- Kate Medetgul-Ernar
- Department of Medicine, Division of Medical Genetics, University of California San Diego
- Ray W. Bowman
- Department of Biological Sciences, University of Pittsburgh
- Cameron P. Hines
- Department of Medicine, Division of Medical Genetics, University of California San Diego
- John Iannotta
- Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh
- Saurin Bipin Parikh
- Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh
- Aoife McLysaght
- Smurfit Institute of Genetics, Trinity College Dublin, University of Dublin
- Carlos J. Camacho
- Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh
- Allyson F. O’Donnell
- Pittsburgh Center for Evolutionary Biology and Medicine, School of Medicine, University of Pittsburgh
- Trey Ideker
- Department of Medicine, Division of Medical Genetics, University of California San Diego
- Anne-Ruxandra Carvunis
- Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh
- DOI
- https://doi.org/10.1038/s41467-020-14500-z
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 18
Abstract
There is increasing evidence that protein-coding genes can emerge de novo from noncoding genomic regions. Vakirlis et al. propose that sequences encoding transmembrane polypeptides can emerge de novo in thymine-rich genomic regions and provide organisms with fitness benefits.
