Communications Biology (Aug 2021)
A humanized orthotopic tumor microenvironment alters the bone metastatic tropism of prostate cancer cells
- Jacqui A. McGovern,
- Nathalie Bock,
- Abbas Shafiee,
- Laure C. Martine,
- Ferdinand Wagner,
- Jeremy G. Baldwin,
- Marietta Landgraf,
- Christoph A. Lahr,
- Christoph Meinert,
- Elizabeth D. Williams,
- Pamela M. Pollock,
- Jim Denham,
- Pamela J. Russell,
- Gail P. Risbridger,
- Judith A. Clements,
- Daniela Loessner,
- Boris M. Holzapfel,
- Dietmar W. Hutmacher
Affiliations
- Jacqui A. McGovern
- Centre in Regenerative Medicine, Queensland University of Technology (QUT)
- Nathalie Bock
- Centre in Regenerative Medicine, Queensland University of Technology (QUT)
- Abbas Shafiee
- Centre in Regenerative Medicine, Queensland University of Technology (QUT)
- Laure C. Martine
- Centre in Regenerative Medicine, Queensland University of Technology (QUT)
- Ferdinand Wagner
- Centre in Regenerative Medicine, Queensland University of Technology (QUT)
- Jeremy G. Baldwin
- Centre in Regenerative Medicine, Queensland University of Technology (QUT)
- Marietta Landgraf
- Centre in Regenerative Medicine, Queensland University of Technology (QUT)
- Christoph A. Lahr
- Centre in Regenerative Medicine, Queensland University of Technology (QUT)
- Christoph Meinert
- Centre in Regenerative Medicine, Queensland University of Technology (QUT)
- Elizabeth D. Williams
- School of Biomedical Sciences at Translational Research Institute (TRI), Faculty of Health, QUT
- Pamela M. Pollock
- School of Biomedical Sciences at Translational Research Institute (TRI), Faculty of Health, QUT
- Jim Denham
- School of Medicine and Population Health, University of Newcastle
- Pamela J. Russell
- School of Biomedical Sciences at Translational Research Institute (TRI), Faculty of Health, QUT
- Gail P. Risbridger
- Department of Anatomy and Developmental Biology, Faculty of Medicine, Nursing and Health Sciences, Monash University
- Judith A. Clements
- School of Biomedical Sciences at Translational Research Institute (TRI), Faculty of Health, QUT
- Daniela Loessner
- Centre in Regenerative Medicine, Queensland University of Technology (QUT)
- Boris M. Holzapfel
- Centre in Regenerative Medicine, Queensland University of Technology (QUT)
- Dietmar W. Hutmacher
- Centre in Regenerative Medicine, Queensland University of Technology (QUT)
- DOI
- https://doi.org/10.1038/s42003-021-02527-x
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 14
Abstract
McGovern et al. establish an orthotopic, humanized prostate cancer model to study bone metastasis. The authors demonstrate that a humanized tumor microenvironment (TME) influences the metastatic spread of cancer cells to tissue-engineered bone, highlighting the importance of the TME in prostate cancer metastasis to bone.
