Function and Therapeutic Implications of tRNA Derived Small RNAs

Briana Wilson; Anindya Dutta

doi:10.3389/fmolb.2022.888424

Frontiers in Molecular Biosciences (Apr 2022)

Function and Therapeutic Implications of tRNA Derived Small RNAs

Briana Wilson,
Anindya Dutta

Affiliations

Briana Wilson: Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA, United States
Anindya Dutta: Department of Genetics, University of Alabama, Birmingham, AL, United States

DOI: https://doi.org/10.3389/fmolb.2022.888424
Journal volume & issue: Vol. 9

Abstract

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tRNA derived small RNAs are mainly composed of tRNA fragments (tRFs) and tRNA halves (tiRs). Several functions have been attributed to tRFs and tiRs since their initial characterizations, spanning all aspects of regulation of the Central Dogma: from nascent RNA silencing, to post-transcriptional gene silencing, and finally, to translational regulation. The length distribution, sequence diversity, and multifaceted functions of tRFs and tiRs positions them as attractive new models for small RNA therapeutics. In this review, we will discuss the principles of tRF biogenesis and function in order to highlight their therapeutic potential.

Published in Frontiers in Molecular Biosciences

ISSN: 2296-889X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.frontiersin.org/journals/molecular-biosciences

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Abstract

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