Core–Shell Polyvinyl Alcohol (PVA) Base Electrospinning Microfibers for Drug Delivery

Abstract

In this study, electrospun membranes were developed for controlled drug release applications. Both uniaxial Polyvinyl alcohol (PVA) and coaxial fibers with a PVA core and a poly (L-lactic acid) (PLLA) and polycaprolactone (PCL) coating were produced with different coating structures. The best conditions for the manufacture of the fibers were also studied and their morphology was analyzed as a function of the electrospinning parameters. Special attention was paid to the fiber surface morphology of the coaxial fibers, obtaining both porous and non-porous coatings. Bovine serum albumin (BSA) was used as the model protein for the drug release studies and, as expected, the uncoated fibers were determined to have the fastest release kinetics. Different release rates were obtained for the coated fibers, which makes this drug release system suitable for different applications according to the release time required.

Keywords

• electrospinning
• coaxial electrospinning
• Polyvinyl alcohol
• controlled drug release