Viruses
(Jan 2019)
Aerosol and Contact Transmission Following Intranasal Infection of Mice with Japanese Encephalitis Virus
Chunxia Chai,
Rachel Palinski,
Yixuan Xu,
Qiao Wang,
Sanjie Cao,
Yi Geng,
Qin Zhao,
Yiping Wen,
Xiaobo Huang,
Qiguai Yan,
Xiaoping Ma,
Xintian Wen,
Yong Huang,
Xinfeng Han,
Wenjun Ma,
Rui Wu
Affiliations
Chunxia Chai
Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
Rachel Palinski
Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA
Yixuan Xu
Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
Qiao Wang
Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
Sanjie Cao
Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
Yi Geng
College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
Qin Zhao
Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
Yiping Wen
Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
Xiaobo Huang
Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
Qiguai Yan
Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
Xiaoping Ma
Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
Xintian Wen
Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
Yong Huang
Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
Xinfeng Han
Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
Wenjun Ma
Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA
Rui Wu
Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
DOI
https://doi.org/10.3390/v11010087
Journal volume & issue
Vol. 11,
no. 1
Abstract
Read online
The Japanese encephalitis virus (JEV), a causative agent of severe viral encephalitis in humans, has a biological cycle fluctuating between transmission in mosquitoes and avian species and amplification in pigs. Contact transmission of JEV was recently shown in pigs in the absence of arthropod vectors. Here, we show JEV transmission between infected and contact mice and further demonstrate that JEV transmission occurs between animals via aerosols, as both viral RNA and infectious JEV were detected in direct contact- and aerosol-exposed contact animals. The results of this study change our understanding of JEV transmission in densely populated regions and may help to explain JEV outbreaks without the presence of arthropod vectors.
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