Dataset on the epidemiology and genetic diversification of dengue virus (DENV) serotypes and genotypes in Mexico
Eduardo Domínguez-de-la-Cruz,
María de Lourdes Muñoz,
Ericel Hernández-García,
Gerardo Pérez-Ramírez,
Randy E. David,
Joel Navarrete-Espinosa,
Álvaro Díaz-Badillo,
Miguel Moreno-Galeana,
Cesar Armando Brito-Carreón
Affiliations
Eduardo Domínguez-de-la-Cruz
Department of Genetics and Molecular Biology, Center for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV—IPN), Mexico City, Mexico
María de Lourdes Muñoz
Department of Genetics and Molecular Biology, Center for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV—IPN), Mexico City, Mexico; Corresponding author.
Ericel Hernández-García
Department of Genetics and Molecular Biology, Center for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV—IPN), Mexico City, Mexico
Gerardo Pérez-Ramírez
Department of Genetics and Molecular Biology, Center for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV—IPN), Mexico City, Mexico
Randy E. David
Laboratories of Biological Anthropology, University of Kansas, Lawrence, KS, USA
Joel Navarrete-Espinosa
Epidemiology Division, Coordination of Integrated Health Programs, Mexican Social Security Institute, Mexico City, Mexico
Álvaro Díaz-Badillo
University of Texas Rio Grande Valley, Department of Human Genetics and South Texas Diabetes and Obesity Institute, TX, USA
Miguel Moreno-Galeana
Department of Genetics and Molecular Biology, Center for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV—IPN), Mexico City, Mexico
Cesar Armando Brito-Carreón
Department of Genetics and Molecular Biology, Center for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV—IPN), Mexico City, Mexico
Dengue virus (DENV) evolution has had a significant impact on disease pathogenesis, virulence, and epidemiology in Mexico. Novel genotypic variation in DENV serotypes and genotypes may influence the magnitude and severity of dengue epidemics, as evidenced by 2009 data from Veracruz State. The data presented herein is related to the publication entitled “Epidemiological Implications of the Genetic Diversification of Dengue Virus (DENV) Serotypes and Genotypes in Mexico” [1]. Raw data and trees provide epidemiological data on DENV prevalence and a comprehensive phylogeny of both representative sequences collected from an NCBI repository, and 28 additional isolates from acute-phase plasma samples diagnosed with dengue fever or severe dengue (Raw sequencing data is hosted in the public repository Mendeley Data (http://dx.doi.org/10.17632/bf2kdhhf6x.2). Phylogenetic trees for each DENV serotype (DENV-1, -2, -3 and -4) were constructed using these sequences by a maximum likelihood methodology as well as a Bayesian Markov chain Monte Carlo (MCMC) integration approach. Phylogenetic trees exhibited: (1) DENV-1, genotype V, (2) the DENV-2 Asian/American and Asian II genotypes, (3) DENV-3, genotype III, and (4) DENV-4, genotype I. This data can be beneficial for future analyses on DENV serotype and genotype structure and the introduction of novel DENV genotype sequences in the Americas, for the further elucidation of dengue etiology.
