Therapeutic potential of clinically proven natural products in the management of dementia
Farzana Ansari,
Md Sohel,
Md Mahfujul Haque Haidary,
Md Saqline Mostaq,
Shamima Akter,
Asrafun Nahar,
Fatematuz Zohora Labony,
Arman Ahmed,
Mohammed Shamim Hasan,
Mohammad Hasem Babu,
Mohammad Nurul Amin
Affiliations
Farzana Ansari
Department of Biochemistry and Molecular Biology, Laboratory of Nutrition and Health Research, University of Dhaka, Dhaka, 1000, Bangladesh
Md Sohel
Department of Biochemistry and Molecular Biology, Mawlana Bhashani Science and Technology University, Santosh, Tangail, 1902, Bangladesh; Pratyasha Health Biomedical Research Center, Dhaka, 1230, Bangladesh
Md Mahfujul Haque Haidary
Department of Pharmacy, Primeasia University, Dhaka, 1213, Bangladesh
Md Saqline Mostaq
Department of Pharmacy, University of Asia Pacific, Dhaka, 1205, Bangladesh
Shamima Akter
Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, 1230. Bangladesh
Asrafun Nahar
Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, 1230. Bangladesh
Fatematuz Zohora Labony
Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka, 1000, Bangladesh
Arman Ahmed
Department of Pharmacy, Noakhali Science and Technology University, Noakhali, 3814, Bangladesh
Mohammed Shamim Hasan
Department of Pharmacy, Noakhali Science and Technology University, Noakhali, 3814, Bangladesh
Mohammad Hasem Babu
Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, 1230. Bangladesh
Mohammad Nurul Amin
Pratyasha Health Biomedical Research Center, Dhaka, 1230, Bangladesh; Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, 1230. Bangladesh; Corresponding author. Department of Pharmacy Atish Dipankar University of Science and Technology, Dhaka, Bangladesh.
Dementia is a common neurodegenerative disorder connected to damage to nerve cells in the brain. Although some conventional drugs are available for dementia treatments and are still sanctified for dementia patients, their short- and long-term side effects and other limitations make treating patients more challenging. The authors aimed to explain novel options for treating dementia with natural products and unravel some clinically proven natural products. This article systematically reviewed recent studies that have investigated the role of natural products and their bioactive compounds for dementia. PubMed Central, Scopus, and Google Scholar databases of articles were collected, and abstracts were reviewed for relevance to the subject matter.In this review, we provide mechanistic insights of clinically validated natural products, including like- Yokukansan, Souvenaid, BDW, Hupergene, Bacopa monnier, Omega-3, Tramiprostate and Palmitoylethanolamide with which have therapeutic efficacy against dementia in the management of dementia. As shown by studies, certain natural ingredients could be used to treat and prevent dementia. We strongly believe that the medicinal plants and phytoconstituents alone or in combination with other compounds would be effective treatments against dementia with lesser side effects as compared to currently available treatments. Moreover, these products should be studied further in order to develop novel dementia medications.
