Nature Communications (Oct 2018)

ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage

  • Mingdong Liu,
  • Taoling Zeng,
  • Xin Zhang,
  • Chunyan Liu,
  • Zhihui Wu,
  • Luming Yao,
  • Changchuan Xie,
  • Hui Xia,
  • Qi Lin,
  • Liping Xie,
  • Dawang Zhou,
  • Xianming Deng,
  • Hong-Lin Chan,
  • Tong-Jin Zhao,
  • Hong-Rui Wang

DOI
https://doi.org/10.1038/s41467-018-06556-9
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 14

Abstract

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DNA damage can lead to autophagy. Here the authors reveal a molecular mechanism for ATR/Chk1 signaling-induced autophagy in response to DNA damage, through an ATR/Chk1/RhoB-mediated lysosomal recruitment of TSC complex and subsequent mTORC1 inhibition.