Nature Communications (Jan 2020)
Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia
- Franc Llorens,
- Peter Hermann,
- Anna Villar-Piqué,
- Daniela Diaz-Lucena,
- Katarina Nägga,
- Oskar Hansson,
- Isabel Santana,
- Matthias Schmitz,
- Christian Schmidt,
- Daniela Varges,
- Stefan Goebel,
- Julien Dumurgier,
- Henrik Zetterberg,
- Kaj Blennow,
- Claire Paquet,
- Inês Baldeiras,
- Isidro Ferrer,
- Inga Zerr
Affiliations
- Franc Llorens
- Department of Neurology, University Medical Center Göttingen
- Peter Hermann
- Department of Neurology, University Medical Center Göttingen
- Anna Villar-Piqué
- Department of Neurology, University Medical Center Göttingen
- Daniela Diaz-Lucena
- Network center for biomedical research of neurodegenerative diseases (CIBERNED), Institute Carlos III, Ministry of Health
- Katarina Nägga
- Department of Acute Internal Medicine and Geriatrics, Linköping University
- Oskar Hansson
- Memory Clinic, Skåne University Hospital
- Isabel Santana
- Neurology Department, CHUC—Centro Hospitalar e Universitário de Coimbra, CNC- Center for Neuroscience and Cell Biology; Faculty of Medicine, University of Coimbra
- Matthias Schmitz
- Department of Neurology, University Medical Center Göttingen
- Christian Schmidt
- Department of Neurology, University Medical Center Göttingen
- Daniela Varges
- Department of Neurology, University Medical Center Göttingen
- Stefan Goebel
- Department of Neurology, University Medical Center Göttingen
- Julien Dumurgier
- Center of Cognitive Neurology and Inserm U942 Lariboisière Hospital AP-HP University Paris Diderot
- Henrik Zetterberg
- Department of Neurodegenerative Disease, Institute of Neurology, University College London
- Kaj Blennow
- Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital
- Claire Paquet
- Center of Cognitive Neurology and Inserm U942 Lariboisière Hospital AP-HP University Paris Diderot
- Inês Baldeiras
- Neurology Department, CHUC—Centro Hospitalar e Universitário de Coimbra, CNC- Center for Neuroscience and Cell Biology; Faculty of Medicine, University of Coimbra
- Isidro Ferrer
- Network center for biomedical research of neurodegenerative diseases (CIBERNED), Institute Carlos III, Ministry of Health
- Inga Zerr
- Department of Neurology, University Medical Center Göttingen
- DOI
- https://doi.org/10.1038/s41467-020-14373-2
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 11
Abstract
Diagnosis of vascular dementia is hampered by the lack of biochemical markers for this disease. Here, the authors show that vascular dementia is associated with increased lipocalin-2 in cerebrospinal fluid, compared to controls and patients with other forms of dementia.
