Evaluation of a Novel Mutant Strain-Enhanced Inactivated Vaccine for Controlling Infectious Bursal Disease in Chickens

Abstract

Infectious bursal disease (IBD) is a highly contagious viral infection caused by the Infectious bursal disease virus (IBDV), primarily affecting chickens and turkeys. This disease targets immature lymphocytes, causing immune suppression and lymphoid organ damage. IBD’s history dates back to its discovery in 1957, initially named Gumboro disease. Over time, it spread globally, posing significant challenges to the poultry industry. This article presents an overview of IBD, including its epidemiology, clinical symptoms, and vaccination strategies. The study also evaluates the efficacy of a novel mutant strain of IBDV in an inactivated vaccine through antibody titers and bursa index analysis.