Molecules (Jan 2009)

A New Atisane-Type Diterpene from the Bark of the Mangrove Plant Excoecaria Agallocha

  • Zhan Chang Wang,
  • Yi Ming Lin,
  • Cai Huan Ke,
  • Dan Qin Feng,
  • Peng Lin,
  • Jun De Chen,
  • Chong Ling Yan

DOI
https://doi.org/10.3390/molecules14010414
Journal volume & issue
Vol. 14, no. 1
pp. 414 – 422

Abstract

Read online

A new atisane-type diterpene, ent-16α-hydroxy-atisane-3,4-lactone (4) and three known diterpenes, ent-16α-hydroxy-atisane-3-one (1), ent-atisane-3β,16α-diol (2), ent-3,4-seco-16α-hydroxyatis- 4(19)-en -3-oic acid (3) were isolated from the bark of the mangrove plant Excoecaria agallocha. Their structures and relative stereochemistry were elucidated by means of extensive NMR and MS analysis. Compound 3 exhibited significant anti-microfouling activity against the adherence of Pseudomonas pseudoalcaligenes, with an EC50 value of 0.54 ± 0.01 ppm.

Keywords