Evaluation of Antiulcer Activity of Crateva Magna (Lour.) Dc in Wistar Albino Rats

Abstract

The Antiulcer activity of aqueous leaf extract of Crateva magna (Lour) DC. was investigated on Ethanol induced ulcer model and Aspirin induced model in wistar rats. In both models the common parameters determined was ulcer index, ulcer score, gastric pH, free and total acidity, Antioxidant parameters such as glutathione peroxidase, superoxide dismutase, lipid peroxides. The aqueous leaf extract of Crateva magna (Lour) DC. dosage 150, and 300 mg/kg produced significant inhibition of gastric lesion induced by Ethanol induced ulcer and Aspirin induced ulcer. The aqueous leaf extract of Crateva magna (Lour) DC. dosage 150, and 300 mg/kg showed significant reduction in free acidity, total acidity, and ulcer index as compared to disease control. The study indicates that aqueous leaf extract of Crateva magna (Lour) DC. have potential antiulcer activity in both models. These results indicated that Crateva magna (Lour) DC. displayed an antiulcerogenic effect due to its cytoprotective activity. Besides antioxidant potential of plant extract scavenged the free radicals produced by Ethanol induction, Aspirin induced ulcer and healed the ulcers.

Keywords

• ulcer score
• super oxide dismutase
• crateva magna (lour) dc.
• herbal medicine