Кардиоваскулярная терапия и профилактика (Apr 2013)

LIPID TRANSPORT GENETIC POLYMORPHISM AND ANGIOTENSIN-CONVERTING ENZYME I/D GENETIC POLYMORPHISM IN UZBEK PATIENTS WITH UNSTABLE ANGINA AND CORONARY HEART DISEASE IN FAMILY HISTORY

  • R. D. Kurbanov,
  • F. M. Bekmetova,
  • A. B. Shek,
  • L. E. Kan,
  • Sh. U. Khashimov

DOI
https://doi.org/10.15829/1728-8800-2013-2-46-51
Journal volume & issue
Vol. 12, no. 2
pp. 46 – 51

Abstract

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Aim. To study the impact of coronary heart disease (CHD) in family history on the genetic polymorphisms of apolipoprotein (apo) A1, B, and E and angiotensin-converting enzyme (ACE) in Uzbek patients with unstable angina (UA).Material and methods. The study included 125 Uzbek patients with UA. Group I (n=63) had CHD in family history, Group II (n=62) had no CHD in family history, and the control group included 58 healthy individuals. The following genetic polymorphisms were investigated, using the Diatom TM DNA Prep 200 kit (IsoGen Laboratory Ltd.): apoA1 G-A polymorphism; apoB –516C/T polymorphism; apoE ε2/ε3/ε4 polymorphism, and ACE I/D polymorphism.Results. In UA patients, compared to healthy controls, the prevalence of apoA1 A allele was significantly higher (odds ratio (OR) 3,63; 95% confidence interval (CI) 1,63–8,04; p=0,002). The distribution of the “damaging” alleles was similar in Group II and the control group, while Group I demonstrated a significantly higher prevalence of A alleles of the apoA1 G-A polymorphism (OR 5,99; 95% CI 2,52–14,24; p=0,001); ε4 allele of the apoE gene (OR 2,91; 95% CI 1,12–7,62; p=0,044); and D allele of the ACE I/D polymorphism (OR 2,88; 95% CI 1,33–6,27; p=0,024). At the same time, there was no marked difference in the distribution of the T allele of the apoB –516C/T polymorphism.Conclusion. In Uzbek patients with UA, CHD in family history is associated with the higher prevalence of the following “damaging” alleles: A allele (M1-) of the apoA1 G-A polymorphism; ε4 allele of the ApoE gene; and D allele of the ACE I/D polymorphism. There was no significant difference in the distribution of T allele of the apoB –516C/T polymorphism.

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