The role of s-palmitoylation in neurological diseases: implication for zDHHC family

Dan Liao; Yutao Huang; Dan Liu; Dan Liu; Haofuzi Zhang; Xinyu Shi; Xin Li; Peng Luo

doi:10.3389/fphar.2023.1342830

Frontiers in Pharmacology (Jan 2024)

The role of s-palmitoylation in neurological diseases: implication for zDHHC family

Dan Liao,
Yutao Huang,
Dan Liu,
Dan Liu,
Haofuzi Zhang,
Xinyu Shi,
Xin Li,
Peng Luo

Affiliations

Dan Liao: Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi’an, China
Yutao Huang: Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi’an, China
Dan Liu: Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi’an, China
Dan Liu: School of Life Science, Northwest University, Xi’an, China
Haofuzi Zhang: Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi’an, China
Xinyu Shi: Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi’an, China
Xin Li: Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi’an, China
Peng Luo: Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi’an, China

DOI: https://doi.org/10.3389/fphar.2023.1342830
Journal volume & issue: Vol. 14

Abstract

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S-palmitoylation is a reversible posttranslational modification, and the palmitoylation reaction in human-derived cells is mediated by the zDHHC family, which is composed of S-acyltransferase enzymes that possess the DHHC (Asp-His-His-Cys) structural domain. zDHHC proteins form an autoacylation intermediate, which then attaches the fatty acid to cysteine a residue in the target protein. zDHHC proteins sublocalize in different neuronal structures and exert dif-ferential effects on neurons. In humans, many zDHHC proteins are closely related to human neu-rological disor-ders. This review focuses on a variety of neurological disorders, such as AD (Alz-heimer’s disease), HD (Huntington’s disease), SCZ (schizophrenia), XLID (X-linked intellectual disability), attention deficit hyperactivity disorder and glioma. In this paper, we will discuss and summarize the research progress regarding the role of zDHHC proteins in these neu-rological disorders.

Published in Frontiers in Pharmacology

ISSN: 1663-9812 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://journal.frontiersin.org/journals/pharmacology

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