Organocatalytic enantio- and diastereoselective cycloetherification via dynamic kinetic resolution of chiral cyanohydrins

Naoki Yoneda; Yuki Fujii; Akira Matsumoto; Keisuke Asano; Seijiro Matsubara

doi:10.1038/s41467-017-01099-x

Nature Communications (Nov 2017)

Organocatalytic enantio- and diastereoselective cycloetherification via dynamic kinetic resolution of chiral cyanohydrins

Naoki Yoneda,
Yuki Fujii,
Akira Matsumoto,
Keisuke Asano,
Seijiro Matsubara

Affiliations

Naoki Yoneda: Department of Material Chemistry, Graduate School of Engineering, Kyoto University
Yuki Fujii: Department of Material Chemistry, Graduate School of Engineering, Kyoto University
Akira Matsumoto: Department of Material Chemistry, Graduate School of Engineering, Kyoto University
Keisuke Asano: Department of Material Chemistry, Graduate School of Engineering, Kyoto University
Seijiro Matsubara: Department of Material Chemistry, Graduate School of Engineering, Kyoto University

DOI: https://doi.org/10.1038/s41467-017-01099-x
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 7

Abstract

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Enantioselective synthesis of six-membered oxacycles with multiple stereogenic centres is essential for the discovery of new therapeutic agents. Here the authors show organocatalytic cycloetherification for the highly enantio- and diastereoselective synthesis of tetrahydropyrans.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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