Succinate Dehydrogenase, Succinate, and Superoxides: A Genetic, Epigenetic, Metabolic, Environmental Explosive Crossroad
Paule Bénit,
Judith Goncalves,
Riyad El Khoury,
Malgorzata Rak,
Judith Favier,
Anne-Paule Gimenez-Roqueplo,
Pierre Rustin
Affiliations
Paule Bénit
NeuroDiderot, Inserm, Université Paris Cité, F-75019 Paris, France
Judith Goncalves
Paris Centre de Recherche Cardiovasculaire (PARCC), Inserm, Université Paris Cité, F-75015 Paris, France
Riyad El Khoury
Department of Pathology and Laboratory Medicine, Neuromuscular Diagnostic Laboratory, American University of Beirut Medical Center, Beirut 1107 2020, Lebanon
Malgorzata Rak
NeuroDiderot, Inserm, Université Paris Cité, F-75019 Paris, France
Judith Favier
Paris Centre de Recherche Cardiovasculaire (PARCC), Inserm, Université Paris Cité, F-75015 Paris, France
Anne-Paule Gimenez-Roqueplo
Département de Médecine Génomique des Tumeurs et des Cancers, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Européen Georges Pompidou, F-75015 Paris, France
Pierre Rustin
NeuroDiderot, Inserm, Université Paris Cité, F-75019 Paris, France
Research focused on succinate dehydrogenase (SDH) and its substrate, succinate, culminated in the 1950s accompanying the rapid development of research dedicated to bioenergetics and intermediary metabolism. This allowed researchers to uncover the implication of SDH in both the mitochondrial respiratory chain and the Krebs cycle. Nowadays, this theme is experiencing a real revival following the discovery of the role of SDH and succinate in a subset of tumors and cancers in humans. The aim of this review is to enlighten the many questions yet unanswered, ranging from fundamental to clinically oriented aspects, up to the danger of the current use of SDH as a target for a subclass of pesticides.
