Nature Communications (Nov 2022)
FOXQ1 recruits the MLL complex to activate transcription of EMT and promote breast cancer metastasis
- Allison V. Mitchell,
- Ling Wu,
- C. James Block,
- Mu Zhang,
- Justin Hackett,
- Douglas B. Craig,
- Wei Chen,
- Yongzhong Zhao,
- Bin Zhang,
- Yongjun Dang,
- Xiaohong Zhang,
- Shengping Zhang,
- Chuangui Wang,
- Heather Gibson,
- Lori A. Pile,
- Benjamin Kidder,
- Larry Matherly,
- Zhe Yang,
- Yali Dou,
- Guojun Wu
Affiliations
- Allison V. Mitchell
- Barbara Ann Karmanos Cancer Institute, Department of Oncology, Wayne State University School of Medicine
- Ling Wu
- Barbara Ann Karmanos Cancer Institute, Department of Oncology, Wayne State University School of Medicine
- C. James Block
- Barbara Ann Karmanos Cancer Institute, Department of Oncology, Wayne State University School of Medicine
- Mu Zhang
- Barbara Ann Karmanos Cancer Institute, Department of Oncology, Wayne State University School of Medicine
- Justin Hackett
- Barbara Ann Karmanos Cancer Institute, Department of Oncology, Wayne State University School of Medicine
- Douglas B. Craig
- Barbara Ann Karmanos Cancer Institute, Department of Oncology, Wayne State University School of Medicine
- Wei Chen
- Barbara Ann Karmanos Cancer Institute, Department of Oncology, Wayne State University School of Medicine
- Yongzhong Zhao
- Department of Genetics and Genomic Sciences, Icahn Institute of Genomics and Multiscale Biology, Icahn Mount Sinai School of Medicine
- Bin Zhang
- Department of Genetics and Genomic Sciences, Icahn Institute of Genomics and Multiscale Biology, Icahn Mount Sinai School of Medicine
- Yongjun Dang
- Key Laboratory of Metabolism and Molecular Medicine, the Ministry of Education, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University
- Xiaohong Zhang
- Barbara Ann Karmanos Cancer Institute, Department of Oncology, Wayne State University School of Medicine
- Shengping Zhang
- Institute of Translational Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
- Chuangui Wang
- Institute of Translational Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
- Heather Gibson
- Barbara Ann Karmanos Cancer Institute, Department of Oncology, Wayne State University School of Medicine
- Lori A. Pile
- The Department of Biological Sciences, Wayne State University
- Benjamin Kidder
- Barbara Ann Karmanos Cancer Institute, Department of Oncology, Wayne State University School of Medicine
- Larry Matherly
- Barbara Ann Karmanos Cancer Institute, Department of Oncology, Wayne State University School of Medicine
- Zhe Yang
- Department of Biochemistry, Microbiology, and Immunology, Wayne State University School of Medicine
- Yali Dou
- Department of Pathology, University of Michigan Medical School
- Guojun Wu
- Barbara Ann Karmanos Cancer Institute, Department of Oncology, Wayne State University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-022-34239-z
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 22
Abstract
Forkhead box transcription factor, FOXQ1 is reported to promote epithelial-mesenchymal transition (EMT) and cancer metastasis. Here the authors show that FOXQ1 recruits the KMT2/MLL histone methyltransferase complex as a transcriptional coactivator to activate EMT programme in breast cancer.
