Filopodia-based contact stimulation of cell migration drives tissue morphogenesis

Maik C. Bischoff; Sebastian Lieb; Renate Renkawitz-Pohl; Sven Bogdan

doi:10.1038/s41467-020-20362-2

Nature Communications (Feb 2021)

Filopodia-based contact stimulation of cell migration drives tissue morphogenesis

Maik C. Bischoff,
Sebastian Lieb,
Renate Renkawitz-Pohl,
Sven Bogdan

Affiliations

Maik C. Bischoff: Institute of Physiology and Pathophysiology, Department of Molecular Cell Physiology, Philipps-University
Sebastian Lieb: Computer Graphics and Multimedia Programming, Philipps-University
Renate Renkawitz-Pohl: Developmental Biology, Philipps-University
Sven Bogdan: Institute of Physiology and Pathophysiology, Department of Molecular Cell Physiology, Philipps-University

DOI: https://doi.org/10.1038/s41467-020-20362-2
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 18

Abstract

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Contact stimulation of migration drives tissue morphogenesis. Here the authors report that filopodia-based contact-dependent asymmetry of cell–matrix adhesion drives directional movement, whereas contractile actin cables contribute to the integrity of the migrating cell cluster in the myotubes of Drosophila developing testes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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