Kirkuk Journal of Science (Jun 2018)

Synthesis and Identification of Heterocyclic Compounds Derived from Ciprofloxacin

  • Shaima Ibraheem Chyad AL-khazraji

DOI
https://doi.org/10.32894/kujss.2018.145900
Journal volume & issue
Vol. 13, no. 2
pp. 365 – 382

Abstract

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This research included preparation of Heterogeneous Cyclic compounds (quadrilateral and pentalateral) based on the acidic form of Ciprofloxacin (1) as a starting material. The ester compound (2) was prepared by reacting (1) with ethanol in the presence of sulphuric acid, followed by the reaction with hydrazine-hydrite to obtain the hydrazide compound (3), which was treated with aromatic aldehydes in the presence of absolute ethanol as a solvent to give the Schiff bases (4-6). The quadrilateral cyclo derivatives of B-Lactam (7, 9, 11) were prepared by reacting the Schiff bases with chloroacetyl chloride, using 1,4-dioxan as a solvent and trimethyl amine as a base. The pentalateral oxazolidine cyclo compounds (8, 10, 12) were prepared by reacting the Schiff bases with glycolic acid in the presence of 1,4-dioxan as a solvent. All prepared compounds were characterized using IR spectroscopy and melting points to prove the accuracy of the chemical structures

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