Kirkuk Journal of Science (Jun 2018)
Synthesis and Identification of Heterocyclic Compounds Derived from Ciprofloxacin
Abstract
This research included preparation of Heterogeneous Cyclic compounds (quadrilateral and pentalateral) based on the acidic form of Ciprofloxacin (1) as a starting material. The ester compound (2) was prepared by reacting (1) with ethanol in the presence of sulphuric acid, followed by the reaction with hydrazine-hydrite to obtain the hydrazide compound (3), which was treated with aromatic aldehydes in the presence of absolute ethanol as a solvent to give the Schiff bases (4-6). The quadrilateral cyclo derivatives of B-Lactam (7, 9, 11) were prepared by reacting the Schiff bases with chloroacetyl chloride, using 1,4-dioxan as a solvent and trimethyl amine as a base. The pentalateral oxazolidine cyclo compounds (8, 10, 12) were prepared by reacting the Schiff bases with glycolic acid in the presence of 1,4-dioxan as a solvent. All prepared compounds were characterized using IR spectroscopy and melting points to prove the accuracy of the chemical structures
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