Evolution of disease activity and biomarkers on and off rapamycin in 28 patients with autoimmune lymphoproliferative syndrome

• Christian Klemann,
• Myrian Esquivel,
• Aude Magerus-Chatinet,
• Myriam R. Lorenz,
• Ilka Fuchs,
• Nathalie Neveux,
• Martin Castelle,
• Jan Rohr,
• Claudia Bettoni da Cunha,
• Martin Ebinger,
• Robin Kobbe,
• Bernhard Kremens,
• Florian Kollert,
• Eleonora Gambineri,
• Kai Lehmberg,
• Markus G. Seidel,
• Kathrin Siepermann,
• Thomas Voelker,
• Volker Schuster,
• Sigune Goldacker,
• Klaus Schwarz,
• Carsten Speckmann,
• Capucine Picard,
• Alain Fischer,
• Frederic Rieux-Laucat,
• Stephan Ehl,
• Anne Rensing-Ehl,
• Benedicte Neven

Affiliations

Christian Klemann

Center for Chronic Immunodeficiency (CCI), Medical Center, Faculty of Medicine, University of Freiburg, Germany;Center for Pediatrics, Department of Pediatric Hematology and Oncology, University Medical Center, Faculty of Medicine, University of Freiburg, Germany

Myrian Esquivel

INSERM UMR 1163, Laboratory of the immunogenetics of Pediatric Autoimmune Diseases, Paris, France;Unite d’Immuno Hematologie Pediatrique, Hopital Necker-Enfants Malades, Assistance Publique des Hopitaux de Paris, France

Aude Magerus-Chatinet

INSERM UMR 1163, Laboratory of the immunogenetics of Pediatric Autoimmune Diseases, Paris, France;Paris Descartes – Sorbonne Paris Cité University, Imagine Institute, France

Myriam R. Lorenz

Institute for Transfusion Medicine, University of Ulm, Germany;Institute for Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Service, Germany

Ilka Fuchs

Center for Chronic Immunodeficiency (CCI), Medical Center, Faculty of Medicine, University of Freiburg, Germany

Nathalie Neveux

Service de Biochimie, Hopital Cochin, Assistance Publique Hopitaux de Paris, France

Martin Castelle

Unite d’Immuno Hematologie Pediatrique, Hopital Necker-Enfants Malades, Assistance Publique des Hopitaux de Paris, France

Jan Rohr

Center for Chronic Immunodeficiency (CCI), Medical Center, Faculty of Medicine, University of Freiburg, Germany;Center for Pediatrics, Department of Pediatric Hematology and Oncology, University Medical Center, Faculty of Medicine, University of Freiburg, Germany

Claudia Bettoni da Cunha

Department of Pediatric Hematology and Oncology, Hannover Medical School, Germany

Martin Ebinger

University Children’s Hospital Tübingen, Germany

Robin Kobbe

Department of Pediatrics, Infectious Diseases and Immunity, University Medical Centre Hamburg-Eppendorf, Germany

Bernhard Kremens

Department of Rheumatology and Clinical Immunology, University Medical Centre Freiburg, Germany

Florian Kollert

University Hospital Essen, Department of Paediatrics III, University of Duisburg-Essen, Germany

Eleonora Gambineri

Department of “NEUROFARBA”: Section of Child’s Health, University of Florence, Department of Haematology-Oncology: BMT Unit, Department of Fetal and Neonatal Medicine: Rare Diseases, “Anna Meyer” Children’s Hospital, Florence, Italy

Kai Lehmberg

Department of Pediatric Haematology/Oncology, University Medical Centre Hamburg, Germany

Markus G. Seidel

Division of Pediatric Hematology-Oncology, Department of Pediatrics and Adolescent Medicine, Medical University Graz, Austria

Kathrin Siepermann

Department of Pediatric and Adolescent Medicine, HELIOS Klinikum Krefeld, Germany

Thomas Voelker

Hospital for Pediatric Haematology and Oncology, Medical Center Kassel GmbH, Germany

Volker Schuster

Hospital for Children and Adolescents, University of Leipzig, Germany

Sigune Goldacker

Center for Chronic Immunodeficiency (CCI), Medical Center, Faculty of Medicine, University of Freiburg, Germany

Klaus Schwarz

Institute for Transfusion Medicine, University of Ulm, Germany;Institute for Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Service, Germany

Carsten Speckmann

Center for Chronic Immunodeficiency (CCI), Medical Center, Faculty of Medicine, University of Freiburg, Germany;Center for Pediatrics, Department of Pediatric Hematology and Oncology, University Medical Center, Faculty of Medicine, University of Freiburg, Germany

Capucine Picard

INSERM UMR 1163, Laboratory of the immunogenetics of Pediatric Autoimmune Diseases, Paris, France;Unite d’Immuno Hematologie Pediatrique, Hopital Necker-Enfants Malades, Assistance Publique des Hopitaux de Paris, France;Centre d’Etude des Deficits Immunitaires, Hopital Necker-Enfants Malades, Assistance Publique des Hopitaux de Paris, France

Alain Fischer

INSERM UMR 1163, Laboratory of the immunogenetics of Pediatric Autoimmune Diseases, Paris, France;Unite d’Immuno Hematologie Pediatrique, Hopital Necker-Enfants Malades, Assistance Publique des Hopitaux de Paris, France;College de France, Paris, France

Frederic Rieux-Laucat

INSERM UMR 1163, Laboratory of the immunogenetics of Pediatric Autoimmune Diseases, Paris, France;Paris Descartes – Sorbonne Paris Cité University, Imagine Institute, France

Stephan Ehl

Center for Chronic Immunodeficiency (CCI), Medical Center, Faculty of Medicine, University of Freiburg, Germany;Center for Pediatrics, Department of Pediatric Hematology and Oncology, University Medical Center, Faculty of Medicine, University of Freiburg, Germany

Anne Rensing-Ehl

Center for Chronic Immunodeficiency (CCI), Medical Center, Faculty of Medicine, University of Freiburg, Germany

Benedicte Neven

Unite d’Immuno Hematologie Pediatrique, Hopital Necker-Enfants Malades, Assistance Publique des Hopitaux de Paris, France