Frontiers in Immunology (Jan 2020)
Salp15, a Multifunctional Protein From Tick Saliva With Potential Pharmaceutical Effects
- Shiyuan Wen,
- Shiyuan Wen,
- Shiyuan Wen,
- Shiyuan Wen,
- Feng Wang,
- Feng Wang,
- Feng Wang,
- Zhenhua Ji,
- YingYi Pan,
- Miaomiao Jian,
- Miaomiao Jian,
- YunFeng Bi,
- YunFeng Bi,
- YunFeng Bi,
- Guozhong Zhou,
- Guozhong Zhou,
- Guozhong Zhou,
- Lisha Luo,
- Lisha Luo,
- Taigui Chen,
- Lianbao Li,
- Zhe Ding,
- Manzama-Esso Abi,
- Aihua Liu,
- Aihua Liu,
- Aihua Liu,
- Fukai Bao,
- Fukai Bao,
- Fukai Bao
Affiliations
- Shiyuan Wen
- Department of Microbiology and Immunology, Kunming Medical University, Kunming, China
- Shiyuan Wen
- The Center of Tropical Diseases, The Institute for Tropical Medicine, Kunming Medical University, Kunming, China
- Shiyuan Wen
- Yunnan Demonstration Base of International Science and Technology Cooperation for Tropical Diseases, Kunming, China
- Shiyuan Wen
- The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, China
- Feng Wang
- Department of Microbiology and Immunology, Kunming Medical University, Kunming, China
- Feng Wang
- The Center of Tropical Diseases, The Institute for Tropical Medicine, Kunming Medical University, Kunming, China
- Feng Wang
- Yunnan Demonstration Base of International Science and Technology Cooperation for Tropical Diseases, Kunming, China
- Zhenhua Ji
- Department of Microbiology and Immunology, Kunming Medical University, Kunming, China
- YingYi Pan
- Department of Microbiology and Immunology, Kunming Medical University, Kunming, China
- Miaomiao Jian
- The Center of Tropical Diseases, The Institute for Tropical Medicine, Kunming Medical University, Kunming, China
- Miaomiao Jian
- Department of Biochemistry and Molecular Biology, Kunming Medical University, Kunming, China
- YunFeng Bi
- Department of Microbiology and Immunology, Kunming Medical University, Kunming, China
- YunFeng Bi
- The Center of Tropical Diseases, The Institute for Tropical Medicine, Kunming Medical University, Kunming, China
- YunFeng Bi
- Yunnan Demonstration Base of International Science and Technology Cooperation for Tropical Diseases, Kunming, China
- Guozhong Zhou
- Department of Microbiology and Immunology, Kunming Medical University, Kunming, China
- Guozhong Zhou
- The Center of Tropical Diseases, The Institute for Tropical Medicine, Kunming Medical University, Kunming, China
- Guozhong Zhou
- Yunnan Demonstration Base of International Science and Technology Cooperation for Tropical Diseases, Kunming, China
- Lisha Luo
- The Center of Tropical Diseases, The Institute for Tropical Medicine, Kunming Medical University, Kunming, China
- Lisha Luo
- Department of Biochemistry and Molecular Biology, Kunming Medical University, Kunming, China
- Taigui Chen
- Department of Microbiology and Immunology, Kunming Medical University, Kunming, China
- Lianbao Li
- Department of Microbiology and Immunology, Kunming Medical University, Kunming, China
- Zhe Ding
- Department of Microbiology and Immunology, Kunming Medical University, Kunming, China
- Manzama-Esso Abi
- Department of Microbiology and Immunology, Kunming Medical University, Kunming, China
- Aihua Liu
- The Center of Tropical Diseases, The Institute for Tropical Medicine, Kunming Medical University, Kunming, China
- Aihua Liu
- Yunnan Demonstration Base of International Science and Technology Cooperation for Tropical Diseases, Kunming, China
- Aihua Liu
- Department of Biochemistry and Molecular Biology, Kunming Medical University, Kunming, China
- Fukai Bao
- Department of Microbiology and Immunology, Kunming Medical University, Kunming, China
- Fukai Bao
- The Center of Tropical Diseases, The Institute for Tropical Medicine, Kunming Medical University, Kunming, China
- Fukai Bao
- Yunnan Demonstration Base of International Science and Technology Cooperation for Tropical Diseases, Kunming, China
- DOI
- https://doi.org/10.3389/fimmu.2019.03067
- Journal volume & issue
-
Vol. 10
Abstract
Ixodes ticks are the main vectors for a number of zoonotic diseases, including Lyme disease. Ticks secrete saliva directly into a mammalian host while feeding on the host's blood. This action serves to modulate host immunity and coagulation, thus allowing ticks to attach and feed upon their host. One of the most extensively studied components of tick saliva is Salp15. Research has shown that this protein binds specifically to CD4 molecules on the surface of T lymphocytes, interferes with TCR-mediated signaling transduction, inhibits CD4+ T cell activation and proliferation, and impedes the secretion of interleukin 2 (IL-2). Salp15 also binds specifically to dendritic cell dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) to up-regulate the expression of CD73 in regulatory T cells. Collectively, these findings render this salivary protein a potential candidate for a range of therapeutic applications. Here, we discuss our current understanding of Salp15 and the mechanisms that might be used to treat disease.
Keywords
