Fertility & Reproduction (Dec 2023)
#388 : Clinical Outcomes of Modified Natural Cycle Versus Hormone Replacement Therapy for Endometrial Preparation for Frozen Embryo Transfer
Abstract
Background and Aims: Frozen embryo transfer is a current trend in practice worldwide. Modified Natural Cycle, Hormone Replacement Therapy are common endometrial preparation protocols in Vietnam. The aim of this study was to compare the outcomes of a Modified Natural Cycle vs Hormone Replacement Therapy for Endometrial Preparation for Frozen Embryo Transfer. Method: This was a single center randomized clinical trial. It was conducted in the period between August 2022 and March 2023 in Andrology and Fertility Hospital of Hanoi. A total of 166 patients were randomly allocated to two groups, either the hormone replacement cycle (83 patients) (HRT group) or the modified natural cycle (83 patients) (mNC group). Results: The mean age was 31 vs 30 years in mNC and HRT. The endometrial thickness on the day of Progesterone administration in mNC was higher than HRT (10.99±1.46 và 10.70±1.06 mm), p>0.05. There was no significant difference between mNC group and HRT group regarding implantation rate, clinical pregnancy rate, on-going rate. After adjusting for age, BMI, duration of infertility, type of infertility, history of miscarriage, number of failed embryo transfers, endometrial thickness on the day of Progesterone administration, number of good-quality embryos transferred showed that the clinical pregnancy rate in the HRT was higher than that mNC, but the relationship was not statistically significant with p>0.05. Conclusion: The selection of regimen to use for endometrial preparation for frozen embryo transfer depends on individualized patient treatment, particularly with respect to the selection of the endometrial preparation method particularly with respect to the selection of the endometrial preparation method.
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