Rapid transmission and tight bottlenecks constrain the evolution of highly transmissible SARS-CoV-2 variants

Emily E. Bendall; Amy P. Callear; Amy Getz; Kendra Goforth; Drew Edwards; Arnold S. Monto; Emily T. Martin; Adam S. Lauring

doi:10.1038/s41467-023-36001-5

Nature Communications (Jan 2023)

Rapid transmission and tight bottlenecks constrain the evolution of highly transmissible SARS-CoV-2 variants

Emily E. Bendall,
Amy P. Callear,
Amy Getz,
Kendra Goforth,
Drew Edwards,
Arnold S. Monto,
Emily T. Martin,
Adam S. Lauring

Affiliations

Emily E. Bendall: Department of Microbiology and Immunology, University of Michigan
Amy P. Callear: Department of Epidemiology, University of Michigan
Amy Getz: Department of Epidemiology, University of Michigan
Kendra Goforth: Department of Epidemiology, University of Michigan
Drew Edwards: Department of Epidemiology, University of Michigan
Arnold S. Monto: Department of Epidemiology, University of Michigan
Emily T. Martin: Department of Epidemiology, University of Michigan
Adam S. Lauring: Department of Microbiology and Immunology, University of Michigan

DOI: https://doi.org/10.1038/s41467-023-36001-5
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 7

Abstract

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Here, by sequencing viruses from individuals in multiple households, Bendall et al. find that SARS-CoV-2 transmission bottleneck does not vary between individuals infected with pre-variant lineages and those infected with highly transmissible Alpha, Delta, or Omicron variants, suggesting these tight bottlenecks will limit the spread of new mutations.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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