Endothelial senescence and microRNA

Abstract

Cellular senescence occurs when cells lose the ability to divide and proliferate. Endothelial cell senescence is associated with vascular diseases, such as atherosclerosis. In this review, I discuss the factors affecting endothelial cell senescence. Then I describe the role of microRNAs (miRNAs) in endothelial cell senescence. Understanding miRNA pathways in endothelial senescence may lead to new treatments for endothelial dysfunction and atherosclerosis.

Keywords

• endothelial cells
• microrna
• senescence
• sirt1