Potential Cancer- and Alzheimer’s Disease-Targeting Phosphodiesterase Inhibitors from Uvaria alba: Insights from In Vitro and Consensus Virtual Screening

• Mark Tristan Quimque,
• Kin Israel Notarte,
• Arianne Letada,
• Rey Arturo Fernandez,
• Delfin Yñigo Pilapil,
• Kirstin Rhys Pueblos,
• Jay Carl Agbay,
• Hans-Martin Dahse,
• Arlette Wenzel-Storjohann,
• Deniz Tasdemir,
• Abbas Khan,
• Dong-Qing Wei,
• Allan Patrick Gose Macabeo

Affiliations

Mark Tristan Quimque

Laboratory of Organic Reactivity, Discovery & Synthesis (LORDS), Research Center for Natural & Applied Sciences, University of Santo Tomas, Manila, Philippines

Kin Israel Notarte

Laboratory of Organic Reactivity, Discovery & Synthesis (LORDS), Research Center for Natural & Applied Sciences, University of Santo Tomas, Manila, Philippines

Arianne Letada

Laboratory of Organic Reactivity, Discovery & Synthesis (LORDS), Research Center for Natural & Applied Sciences, University of Santo Tomas, Manila, Philippines

Rey Arturo Fernandez

Laboratory of Organic Reactivity, Discovery & Synthesis (LORDS), Research Center for Natural & Applied Sciences, University of Santo Tomas, Manila, Philippines

Delfin Yñigo Pilapil

Laboratory of Organic Reactivity, Discovery & Synthesis (LORDS), Research Center for Natural & Applied Sciences, University of Santo Tomas, Manila, Philippines

Kirstin Rhys Pueblos

Laboratory of Organic Reactivity, Discovery & Synthesis (LORDS), Research Center for Natural & Applied Sciences, University of Santo Tomas, Manila, Philippines

Jay Carl Agbay

Department of Chemistry, College of Science and Mathematics, Mindanao State University-Iligan Institute of Technology, Iligan City, Philippines

Hans-Martin Dahse

Leibniz-Institute for Natural Product Research and Infection Biology, Hans-Knöll-Institute (HKI), Jena, Germany

Arlette Wenzel-Storjohann

GEOMAR Centre for Marine Biotechnology (GEOMAR-Biotech), Research Unit, Marine Natural Products Chemistry, GEOMAR Helmholtz Centre for Ocean Research Kiel, Kiel, Germany

Deniz Tasdemir

GEOMAR Centre for Marine Biotechnology (GEOMAR-Biotech), Research Unit, Marine Natural Products Chemistry, GEOMAR Helmholtz Centre for Ocean Research Kiel, Kiel, Germany

Abbas Khan

Department of Bioinformatics and Biostatistics, State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai, China

Dong-Qing Wei

Department of Bioinformatics and Biostatistics, State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai, China

Allan Patrick Gose Macabeo

Laboratory of Organic Reactivity, Discovery & Synthesis (LORDS), Research Center for Natural & Applied Sciences, University of Santo Tomas, Manila, Philippines