Super-resolution imaging reveals α-synuclein seeded aggregation in SH-SY5Y cells

Jason C. Sang; Eric Hidari; Georg Meisl; Rohan T. Ranasinghe; Maria Grazia Spillantini; David Klenerman

doi:10.1038/s42003-021-02126-w

Communications Biology (May 2021)

Super-resolution imaging reveals α-synuclein seeded aggregation in SH-SY5Y cells

Jason C. Sang,
Eric Hidari,
Georg Meisl,
Rohan T. Ranasinghe,
Maria Grazia Spillantini,
David Klenerman

Affiliations

Jason C. Sang: Department of Chemistry, University of Cambridge
Eric Hidari: Department of Chemistry, University of Cambridge
Georg Meisl: Department of Chemistry, University of Cambridge
Rohan T. Ranasinghe: Department of Chemistry, University of Cambridge
Maria Grazia Spillantini: Department of Clinical Neuroscience, University of Cambridge
David Klenerman: Department of Chemistry, University of Cambridge

DOI: https://doi.org/10.1038/s42003-021-02126-w
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 11

Abstract

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Jason Sang et al. use super-resolution microscopy to monitor α-synuclein aggregation and uptake in SH-SY5Y neuroblastoma cells. Their results suggest that cells secrete nanoscopic aggregates in response to disruption of protein homeostasis by these α-synuclein seeds, and may represent a protective response by cells to protein aggregation.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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