Communications Biology (May 2021)

Super-resolution imaging reveals α-synuclein seeded aggregation in SH-SY5Y cells

  • Jason C. Sang,
  • Eric Hidari,
  • Georg Meisl,
  • Rohan T. Ranasinghe,
  • Maria Grazia Spillantini,
  • David Klenerman

DOI
https://doi.org/10.1038/s42003-021-02126-w
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 11

Abstract

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Jason Sang et al. use super-resolution microscopy to monitor α-synuclein aggregation and uptake in SH-SY5Y neuroblastoma cells. Their results suggest that cells secrete nanoscopic aggregates in response to disruption of protein homeostasis by these α-synuclein seeds, and may represent a protective response by cells to protein aggregation.