OncoTargets and Therapy (Dec 2019)
Brain Metastases Completely Disappear in Non-Small Cell Lung Cancer Using Hydrogen Gas Inhalation: A Case Report
Abstract
Jibing Chen,1 Feng Mu,1 Tianyu Lu,1 Duanming Du,2 Kecheng Xu1 1Fuda Cancer Hospital of Jinan University, Guangzhou 510665, People’s Republic of China; 2Intervention Department of Shenzhen Second People’s Hospital, Shenzhen 518035, People’s Republic of ChinaCorrespondence: Kecheng XuFuda Cancer Hospital of Jinan University, No. 2 of Tangde West Road, Tianhe District, Guangzhou 510665, People’s Republic of ChinaEmail [email protected] DuIntervention Department of Shenzhen Second People’s Hospital, No. 3002 of Sungang West Road, Futian District, Shenzhen 518035, People’s Republic of ChinaEmail [email protected]: Lung cancer is the most common type of tumor, prone to contralateral lung, bone and brain metastasis. We report a 44-year-old woman diagnosed with lung cancer with multiple metastases in November 2015. Oral targeted drugs were initiated after the removal of brain metastases, and most lesions remained stable for 28 months. In March 2018, intracranial multiple metastases, as well as hydrocephalus accumulation in the third ventricle and lateral ventricles, and metastases in bone, adrenal gland, liver were noted. Hydrogen-gas monotherapy was started to control the tumor a month later. After 4 months, the size of multiple brain tumors was reduced significantly, and the amount of hydrocephalus in the third ventricle and lateral ventricles reduced significantly. After 1 year, all brain tumors had disappeared, and there were no significant changes in metastases in the liver and lung. These data show that, after standard treatments had failed, hydrogen-gas monotherapy elicited significant effective control of tumors (especially those in the brain), and survival time was lengthened.Keywords: hydrogen gas, lung cancer, brain metastasis, extrapulmonary metastasis
