Protective effect of nerve growth factor associated with ginkgo biloba extraction on acute glaucoma retinal ischemia reperfusion injury in rabbit

Abstract

AIM: To investigate the protective effect of nerve growth factor combined with Ginkgo biloba extract on retinal ischemia - reperfusion(RIR)injury in rabbits with experimental high intraocular pressure. METHODS: Establishment of rabbit glaucoma ischemia reperfusion model. Twenty-four New Zealand white rabbits were randomly divided into three groups: nerve growth factor group, Ginkgo biloba extract group and combination group. Respectively, in the continuous administration of 1, 7, 14d. We observed the morphological changes of the tissues of the retina. The levels of superoxide dismutase(SOD), nitric oxide(NO)and malondialdehyde(MDA)in retinal tissue were measured. RESULTS: Respectively, first, in the continuous administration of 1, 7, 14d, the contents of MDA and NO in Ginkgo biloba extract group and nerve growth group were higher than that in combination group(PPPCONCLUSION: Nerve growth factor combined with Ginkgo biloba extract has better protective effect on retinal ischemia-reperfusion injury. The mechanism may be related to the decrease of free radicals and increase the activity of SOD in retinal tissue.

Keywords

• nerve growth factor
• ginkgo biloba extraction
• glaucoma
• ischemia-reperfusion injury
• retinal ganglion cells
• retinal ganglion cells