Nature Communications (Aug 2022)
Flavin-enabled reductive and oxidative epoxide ring opening reactions
- Bidhan Chandra De,
- Wenjun Zhang,
- Chunfang Yang,
- Attila Mándi,
- Chunshuai Huang,
- Liping Zhang,
- Wei Liu,
- Mark W. Ruszczycky,
- Yiguang Zhu,
- Ming Ma,
- Ghader Bashiri,
- Tibor Kurtán,
- Hung-wen Liu,
- Changsheng Zhang
Affiliations
- Bidhan Chandra De
- Key Laboratory of Tropical Marine Bioresources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences
- Wenjun Zhang
- Key Laboratory of Tropical Marine Bioresources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences
- Chunfang Yang
- Key Laboratory of Tropical Marine Bioresources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences
- Attila Mándi
- Department of Organic Chemistry, University of Debrecen
- Chunshuai Huang
- Key Laboratory of Tropical Marine Bioresources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences
- Liping Zhang
- Key Laboratory of Tropical Marine Bioresources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences
- Wei Liu
- Key Laboratory of Tropical Marine Bioresources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences
- Mark W. Ruszczycky
- Division of Chemical Biology & Medicinal Chemistry, College of Pharmacy, and Department of Chemistry, University of Texas at Austin
- Yiguang Zhu
- Key Laboratory of Tropical Marine Bioresources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences
- Ming Ma
- State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University
- Ghader Bashiri
- Laboratory of Molecular and Microbial Biochemistry, School of Biological Sciences, The University of Auckland
- Tibor Kurtán
- Department of Organic Chemistry, University of Debrecen
- Hung-wen Liu
- Division of Chemical Biology & Medicinal Chemistry, College of Pharmacy, and Department of Chemistry, University of Texas at Austin
- Changsheng Zhang
- Key Laboratory of Tropical Marine Bioresources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences
- DOI
- https://doi.org/10.1038/s41467-022-32641-1
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 13
Abstract
Epoxide ring opening reactions are important in both biological processes and synthetic applications. Here, the authors show that flavin cofactors can catalyze reductive and oxidative epoxide ring opening reactions and propose the underlying mechanisms.
