Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex

G. O. Sipe; R. L. Lowery,; M-È Tremblay; E. A. Kelly; C. E. Lamantia; A. K. Majewska

doi:10.1038/ncomms10905

Nature Communications (Mar 2016)

Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex

G. O. Sipe,
R. L. Lowery,,
M-È Tremblay,
E. A. Kelly,
C. E. Lamantia,
A. K. Majewska

Affiliations

G. O. Sipe: Department of Neuroscience, University of Rochester
R. L. Lowery,: Department of Neuroscience, University of Rochester
M-È Tremblay: Department of Neuroscience, University of Rochester
E. A. Kelly: Department of Neuroscience, University of Rochester
C. E. Lamantia: Department of Neuroscience, University of Rochester
A. K. Majewska: Department of Neuroscience, University of Rochester

DOI: https://doi.org/10.1038/ncomms10905
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 15

Abstract

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Microglia play key roles during early neurodevelopment. Here the authors show that microglia are important mediators of ocular dominance plasticity (ODP). Microglia respond to monocular deprivation during the visual critical period, and disrupting microglial P2Y12 purinergic receptor abrogates ODP.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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