High-risk HLA alleles for severe acute graft-versus-host disease and mortality in unrelated donor bone marrow transplantation
Satoko Morishima,
Koichi Kashiwase,
Keitaro Matsuo,
Fumihiro Azuma,
Toshio Yabe,
Aiko Sato-Otsubo,
Seishi Ogawa,
Takashi Shiina,
Masahiro Satake,
Hiroh Saji,
Shunichi Kato,
Yoshihisa Kodera,
Takehiko Sasazuki,
Yasuo Morishima
Affiliations
Satoko Morishima
Department of Hematology, Fujita Health University School of Medicine, Toyoake, Aichi, Tokyo, Japan
Koichi Kashiwase
Japanese Red Cross Kanto-Koshinetsu Block Blood Center, Tokyo, Japan
Keitaro Matsuo
Divsion of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan
Fumihiro Azuma
Japanese Red Cross Kanto-Koshinetsu Block Blood Center, Tokyo, Japan
Toshio Yabe
Japanese Red Cross Kanto-Koshinetsu Block Blood Center, Tokyo, Japan
Aiko Sato-Otsubo
Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Japan
Seishi Ogawa
Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Japan
Takashi Shiina
Division of Basic Medical Science and Molecular Medicine, Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa, Japan
Masahiro Satake
Japanese Red Cross Kanto-Koshinetsu Block Blood Center, Tokyo, Japan
Hiroh Saji
HLA Foundation Laboratory, Kyoto, Japan
Shunichi Kato
Department of Cell Transplantation and Regenerative Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan
Yoshihisa Kodera
Department of Promotion for Blood and Marrow Transplantation, Aichi Medical University School of Medicine, Nagakute, Japan
Takehiko Sasazuki
Institute for Advanced Study, Kyushu University, Fukuoka, Japan
Yasuo Morishima
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
HLA molecules play an important role for immunoreactivity in allogeneic hematopoietic stem cell transplantation. To elucidate the effect of specific HLA alleles on acute graft-versus-host disease, we conducted a retrospective analysis using 6967 Japanese patients transplanted with T-cell-replete marrow from an unrelated donor. Using unbiased searches of patient and donor HLA alleles, patient and/or donor HLA-B*51:01 (patient: HR, 1.37, P
