Markers of fibrosis, renal function in ischemic chronic heart failure in late stage of the postinfarction remodeling

Abstract

Aim. Investigate the levels of fibrosis markers, state of renal function in patients with chronic heart failure in late stage of the postinfarction remodeling. Methods and results. Features of the fibrosis markers and renal function depending on the prior myocardial infarction were identified in 318 patients with ischemic chronic heart failure using ELISA, echocardiography. Activity biomarkers (galectin-3, ST2, NGAL, PICP, cystatin C), estimated glomerular filtration rate, structural and functional parameters of the heart were studied. It was established that the presence of prior myocardial infarction in chronic heart failure was accompanied by the increasing of NT-proBNP, galectin-3, PICP, NGAL and was characterized by structural remodeling of the left atrium with increased systolic pressure in the pulmonary artery, the deterioration of systolic and diastolic function. Conclusion. Galectin-3, PICP, NGAL can be used as new therapeutic targets in patients with myocardial infarction to reduce the degree of fibrosis, inflammation and for preventing development of chronic heart failure and renal dysfunction.

Keywords

• Heart Failure
• Biomarkers
• Fibrosis
• Kidney