Bioengineering of functional human induced pluripotent stem cell-derived intestinal grafts

Kentaro Kitano; Dana M. Schwartz; Haiyang Zhou; Sarah E. Gilpin; Gregory R. Wojtkiewicz; Xi Ren; Cesar A. Sommer; Amalia V. Capilla; Douglas J. Mathisen; Allan M. Goldstein; Gustavo Mostoslavsky; Harald C. Ott

doi:10.1038/s41467-017-00779-y

Nature Communications (Oct 2017)

Bioengineering of functional human induced pluripotent stem cell-derived intestinal grafts

Kentaro Kitano,
Dana M. Schwartz,
Haiyang Zhou,
Sarah E. Gilpin,
Gregory R. Wojtkiewicz,
Xi Ren,
Cesar A. Sommer,
Amalia V. Capilla,
Douglas J. Mathisen,
Allan M. Goldstein,
Gustavo Mostoslavsky,
Harald C. Ott

Affiliations

Kentaro Kitano: Department of Surgery, Massachusetts General Hospital, Harvard Medical School
Dana M. Schwartz: Department of Surgery, Massachusetts General Hospital, Harvard Medical School
Haiyang Zhou: Department of Surgery, Massachusetts General Hospital, Harvard Medical School
Sarah E. Gilpin: Department of Surgery, Massachusetts General Hospital, Harvard Medical School
Gregory R. Wojtkiewicz: Center for Systems Biology, Massachusetts General Hospital, Richard B. Simches Research Center
Xi Ren: Department of Surgery, Massachusetts General Hospital, Harvard Medical School
Cesar A. Sommer: Center for Regenerative Medicine, Boston University School of Medicine
Amalia V. Capilla: Center for Regenerative Medicine, Boston University School of Medicine
Douglas J. Mathisen: Division of Thoracic Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School
Allan M. Goldstein: Division of Pediatric Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School
Gustavo Mostoslavsky: Center for Regenerative Medicine, Boston University School of Medicine
Harald C. Ott: Division of Thoracic Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School

DOI: https://doi.org/10.1038/s41467-017-00779-y
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 13

Abstract

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There is a need for humanised grafts to treat patients with intestinal failure. Here, the authors generate intestinal grafts by recellularizing native intestinal matrix with human induced pluripotent stem cell-derived epithelium and human endothelium, and show nutrient absorption after transplantation in rats.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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