A functional genomics pipeline identifies pleiotropy and cross-tissue effects within obesity-associated GWAS loci

Amelia C. Joslin; Débora R. Sobreira; Grace T. Hansen; Noboru J. Sakabe; Ivy Aneas; Lindsey E. Montefiori; Kathryn M. Farris; Jing Gu; Donna M. Lehman; Carole Ober; Xin He; Marcelo A. Nóbrega

doi:10.1038/s41467-021-25614-3

Nature Communications (Sep 2021)

A functional genomics pipeline identifies pleiotropy and cross-tissue effects within obesity-associated GWAS loci

Amelia C. Joslin,
Débora R. Sobreira,
Grace T. Hansen,
Noboru J. Sakabe,
Ivy Aneas,
Lindsey E. Montefiori,
Kathryn M. Farris,
Jing Gu,
Donna M. Lehman,
Carole Ober,
Xin He,
Marcelo A. Nóbrega

Affiliations

Amelia C. Joslin: Department of Human Genetics, University of Chicago
Débora R. Sobreira: Department of Human Genetics, University of Chicago
Grace T. Hansen: Department of Human Genetics, University of Chicago
Noboru J. Sakabe: Department of Human Genetics, University of Chicago
Ivy Aneas: Department of Human Genetics, University of Chicago
Lindsey E. Montefiori: Department of Human Genetics, University of Chicago
Kathryn M. Farris: Department of Human Genetics, University of Chicago
Jing Gu: Department of Human Genetics, University of Chicago
Donna M. Lehman: Department of Medicine, University of Texas Health Science Center at San Antonio
Carole Ober: Department of Human Genetics, University of Chicago
Xin He: Department of Human Genetics, University of Chicago
Marcelo A. Nóbrega: Department of Human Genetics, University of Chicago

DOI: https://doi.org/10.1038/s41467-021-25614-3
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

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Many genetic loci have been linked to obesity, but knowledge of their functional mechanisms is limited. Here, the authors perform reporter assays and temporal functional genomics data generation to characterize obesity genetic loci and find that loci often harbor multiple functional variants.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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