Pifu-xingbing zhenliaoxue zazhi (Feb 2021)

Analysis of WB band type and the first test results of CD4+ T lymphocytes in HIV-1 antibody positive patients

  • Miaolin HUANG,
  • Junhe LIANG,
  • Jianqi ZOU,
  • Minchao FENG,
  • Hongzhu CAI,
  • Xi'an ZHONG

DOI
https://doi.org/10.3969/j.issn.1674-8468.2021.01.003
Journal volume & issue
Vol. 28, no. 1
pp. 12 – 14,18

Abstract

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Objective: To analyze the WB band and the first test results of CD4+ T lymphocytes in 226 patients with HIV-1 antibody positive in order to reveal the WB pattern and to explore disease progression and immune status, providing the basis for classification of disease stage. Methods: WB test was used to confirm HIV-1 positive patients, and flow cytometry was used to detect CD4+ T lymphocytes. Results: Among the 226 cases of positive HIV-1 antibody, 79.65% (180/226) of males and 20.35% (46/226) of females showed WB band pattern of all bands and sub-full bands. CD4+ T lymphocyte cell counts<200/μL accounted for 36.73%. The detection rates of p55 and P17 in whole band gradually decreased with disease stages (χ2=92.91, 8.37, 14.62, respectively, all P<0.05). Conclusions: The WB band pattern and the first CD4+ T lymphocyte count of HIV-1 antibody positive patients can help to determine the immune status. Gag subsets of P55 and P17 may serve as a potential determinant of disease progression to AIDS, and an indicator to monitor the progress of disease and to predict the therapeutic efficacy.

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