PLoS ONE (Jan 2018)

Prevalence and type of artefact with spectral domain optical coherence tomography macular ganglion cell imaging in glaucoma surveillance.

  • Mona S Awadalla,
  • Jude Fitzgerald,
  • Nicholas H Andrew,
  • Tiger Zhou,
  • Henry Marshall,
  • Ayub Qassim,
  • Mark Hassall,
  • Robert J Casson,
  • Stuart L Graham,
  • Paul R Healey,
  • Ashish Agar,
  • Anna Galanopoulos,
  • Simon Phipps,
  • Angela Chappell,
  • John Landers,
  • Jamie E Craig

DOI
https://doi.org/10.1371/journal.pone.0206684
Journal volume & issue
Vol. 13, no. 12
p. e0206684

Abstract

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PurposeThe ganglion cell analysis (GCA) of the CIRRUSTM HD-OCT (Carl Zeiss, Meditec; Dublin, CA) provides measurement of the macular ganglion cell-inner plexiform layer (GCIPL) thickness. This study determined the frequency of scan artefacts and errors in GCIPL imaging in individuals undergoing HD-OCT surveillance for glaucoma.MethodA total of 1439 eyes from 721 subjects enrolled in a prospective study assessing predictors of glaucoma progression underwent macular GCIPL imaging with the CIRRUS HD-OCT at recruitment. The prevalence of acquisition errors, segmentation errors, and co-morbid macular pathology was determined.ResultsA total of 87 (6.0%) of the 1439 scans had either acquisition errors, segmentation artefacts, or other macular pathology. The most common co-morbid macular pathology was epiretinal membrane in 2.2% of eyes.ConclusionThe macular GCIPL scan was artefact free in 94% of eyes. However, epiretinal membrane and high myopia can cause scan artefact and should be considered when interpreting the results.