Influence of basal level of the general cholesterol on efficacy of antiviral therapy of the chronic hepatitis with peg-interferon-α 2B and ribavirin

Abstract

Chronic hepatitis С - one of the most widespread bloodborne infections in the world, which represents an important problem as one of the frequent causes of disability of young patients and indications to liver transplantation. One of the less studied, but extremely actual problems is eventual influence of the lipid exchange disturbances on the results of combined antiviral therapy. Influence of hypercholesterinemia on chronic HCV-infection and results of antiviral therapy are not studied enough and have certain scientific and practical value. 144 adults (> 18 years) with HCV-infection, who have passed their first course of antiviral therapy with PegIFNα-2b and ribavirin were surveyed. Low degree of fibrosis (measured by elastography, Fibroscan) or its absence was revealed in 77 patients while 67 patients had the significant fibrosis. Basal level of general cholesterol significantly did not differ in both groups. The level of general cholesterol was significantly above in convalescents despite of liver fibrosis degree. Patients with low fibrosis had significantly high level of general cholesterol in case of sustained viral response (SVR). Contrary in group of patients with the significant fibrosis the similar relations did not detected. Therefore, the baseline hypercholesterinemia is positive, irrespective of fibrosis degree, predictor of SVR.

Keywords

• хронический гепатит С
• гиперхолестеринемия
• предикторы ответа на противовирусную терапию