Association Between Family History in Patients with Primary Gout and Left Ventricular Diastolic Function: A Cross-Sectional Study

Abstract

Wen Wen,1,* Ping Lei,1,* Wantai Dang,2 Liwen Ma,1 Jing Hu,1 Jian Liu1 1Department of Ultrasound, First Affiliated Hospital, Clinical Medical College of Chengdu Medical College, Chengdu, People’s Republic of China; 2Department of Rheumatology, First Affiliated Hospital, Clinical Medical College of Chengdu Medical College, Chengdu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jian Liu, Department of Ultrasound, First Affiliated Hospital of Chengdu Medical College, 278 Baoguang Avenue, Xindu District, Chengdu, Si Chuan, 610500, People’s Republic of China, Email [email protected]: This study aimed to employ echocardiography for measuring the markers of left ventricular (LV) diastolic function to investigate the effects of family history of gout on the LV diastolic function in patients with primary gout.Methods: Two hundred and eighty-four patients with primary gout who visited the Department of Rheumatology and Immunology of the First Affiliated Hospital of Chengdu Medical College from September 2020 to July 2022 were selected and their family history of gout, general information, and laboratory markers were recorded. Parameters of LV diastolic function were measured via echocardiography. The correlation between family history and LV diastolic function markers was analyzed using univariate and multivariate regression and the receiver operating characteristic (ROC) curve analyses.Results: LV diastolic function parameters, peak early mitral diastolic velocity (E)/peak late mitral diastolic velocity (A), and early septal mitral annulus diastolic motion velocity (Sepe’), early lateral mitral annulus diastolic motion velocity (Late’) and their mean (e’), were significantly lower in patients with familial primary gout, while left atrial volume index (LAVI) and E/e’ were markedly elevated in patients with sporadic primary gout. In patients with family history, the proportion of grade ≥ 2 LV diastolic insufficiency was distinctly higher than that in patients without family history (41.6% vs 12.3%). Even after adjusting for confounding variables, LAVI, E/A, Sepe’, Late’, e’, E/e’ were obviously associated with family history of gout. The area under ROC of family history combined with SUA level for identifying grade ≥ 2 LV diastolic insufficiency in patients with primary gout was 0.872 (P< 0.05).Conclusion: Family history of gout was closely related to echocardiographic LV diastolic function parameters in patients with gout, what is more, family history of gout combined with SUA level was found to be a valuable indicator for discriminating grade ≥ 2 LV diastolic insufficiency in patients with primary gout.Keywords: primary gout, family history, echocardiography, left ventricular diastolic function

Keywords

• primary gout
• family history
• echocardiography
• left ventricular diastolic function