Journal of Investigative Medicine High Impact Case Reports (Mar 2021)

A Case of Intravascular Diffuse Large B-Cell Lymphoma Initially Suspected as Interstitial Pneumonia Associated With Systemic Scleroderma

  • Tomoyo Oguri MD, PhD,
  • Shinji Sasada MD, PhD,
  • Yuki Aramaki-Sumii MD,
  • Yumi Tsuchiya MD,
  • Kota Ishioka MD,
  • Saeko Takahashi MD, PhD,
  • Hisako Kunieda MD,
  • Yoshifumi Kimura MD, PhD,
  • Reishi Seki MD,
  • Shigemichi Hirose MD, PhD,
  • Morio Nakamura MD, PhD

DOI
https://doi.org/10.1177/2324709621999226
Journal volume & issue
Vol. 9

Abstract

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Intravascular large B-cell lymphoma (IVLBCL) is a rare form of diffuse LBCL. The patient was a 71-year-old female admitted to our hospital with hypoxia. On admission, chest computed tomography revealed a ground-glass opacity. Interstitial pneumonia associated with systemic scleroderma was suspected because of positive anti-centromere antibody. Thereafter, steroid pulse therapy and plasma exchange were performed. Although ground-glass opacity improved, bilateral pleural effusion appeared, so we performed a random skin biopsy because of her elevated serum lactate dehydrogenase and soluble interleukin-2 receptor levels. The patient was diagnosed with IVLBCL with symptoms improving after 6 cycles of rituximab plus chemotherapy treatment.