The Management of Pregnancy Complicated with the Previable Preterm and Preterm Premature Rupture of the Membranes: What about a Limit of Neonatal Viability?—A Review
Stepan Feduniw,
Zuzanna Gaca,
Olga Malinowska,
Weronika Brunets,
Magdalena Zgliczyńska,
Marta Włodarczyk,
Anna Wójcikiewicz,
Michał Ciebiera
Affiliations
Stepan Feduniw
Department of Reproductive Health, Centre of Postgraduate Medical Education, 01-004 Warsaw, Poland
Zuzanna Gaca
Czerniakowski Hospital, 00-739 Warsaw, Poland
Olga Malinowska
Faculty of Medicine, Medical University of Bialystok, 15-089 Bialystok, Poland
Weronika Brunets
Faculty of Medicine, Lazarski University, 02-662 Warsaw, Poland
Magdalena Zgliczyńska
Department of Obstetrics, Perinatology and Neonatology, Centre of Postgraduate Medical Education, 01-809 Warsaw, Poland
Marta Włodarczyk
Department of Biochemistry and Pharmacogenomics, Faculty of Pharmacy, Medical University of Warsaw, 02-097 Warsaw, Poland
Anna Wójcikiewicz
Second Department of Obstetrics and Gynecology, Centre of Postgraduate Medical Education, 01-809 Warsaw, Poland
Michał Ciebiera
Second Department of Obstetrics and Gynecology, Centre of Postgraduate Medical Education, 01-809 Warsaw, Poland
Preterm premature rupture of the membranes (PPROM) at the limit of viability is associated with low neonatal survival rates and a high rate of neonatal complications in survivors. It carries a major risk of maternal morbidity and mortality. The limit of viability can be defined as the earliest stage of fetal maturity when a fetus has a reasonable chance, although not a high likelihood, for extra-uterine survival. The study reviews available data on preventing preterm delivery caused by the previable PPROM, pregnancy latency, therapeutic options including the use of antibiotics and steroids, neonatal outcomes, and future directions and opportunities.
