Nature Communications (Sep 2018)

Local enrichment of HP1alpha at telomeres alters their structure and regulation of telomere protection

  • Tracy T. Chow,
  • Xiaoyu Shi,
  • Jen-Hsuan Wei,
  • Juan Guan,
  • Guido Stadler,
  • Bo Huang,
  • Elizabeth H. Blackburn

DOI
https://doi.org/10.1038/s41467-018-05840-y
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 13

Abstract

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Chromatin dynamics is thought to play an important role in the maintenance of telomeres, yet how has remained poorly understood. Here the authors locally enrich heterochromatin protein 1α (HP1α) at human telomeres to provide insights into the crosstalk between epigenetic regulations and structural dynamics at the telomeres.