Nature Communications (Mar 2019)

ZEB1 protects skeletal muscle from damage and is required for its regeneration

  • Laura Siles,
  • Chiara Ninfali,
  • Marlies Cortés,
  • Douglas S. Darling,
  • Antonio Postigo

DOI
https://doi.org/10.1038/s41467-019-08983-8
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 18

Abstract

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Following muscle damage, an inflammatory response is associated to activation of satellite cells, which drive muscle repair. Here, the authors show that upregulation of Zeb1 in macrophages and muscle fibres regulates inflammation, and also show a role for Zeb1 in maintenance of satellite cell quiescence.